BindingDB logo
myBDB logout

BDBM50375158 CHEMBL404188

SMILES: NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCOCC4)cc3)ncc2c1=O

InChI Key: InChIKey=ATFIPDDKYWSEQD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50375158   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375158
PNG
(CHEMBL404188)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCOCC4)cc3)ncc2c1=O
Show InChI InChI=1S/C29H30N6O3/c30-27(37)25-18-35(23-9-6-20-2-1-3-21(20)16-23)28-24(26(25)36)17-31-29(33-28)32-22-7-4-19(5-8-22)10-11-34-12-14-38-15-13-34/h4-9,16-18H,1-3,10-15H2,(H2,30,37)(H,31,32,33)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair