BDBM50378739 SINEFUNGIN::jm2c00120, Sinefungin
SMILES N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
InChI Key InChIKey=LMXOHSDXUQEUSF-YECHIGJVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 50378739
TargetProtein-L-isoaspartate(D-aspartate) O-methyltransferase(Homo sapiens (Human))
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataKi: 4.70E+4nMAssay Description:Kinetic constant was measured for Protein Methylase II of Leishmania donovani promastigotes using supernatant (S12) fractionMore data for this Ligand-Target Pair
TargetProtein-L-isoaspartate(D-aspartate) O-methyltransferase(Homo sapiens (Human))
Cnrs
Curated by ChEMBL
Cnrs
Curated by ChEMBL
Affinity DataKi: 1.26E+5nMAssay Description:Kinetic constant was measured for Protein Methylase II of Leishmania donovani promastigotes using protein extracted from the 12000g pellet(P12).More data for this Ligand-Target Pair
TargetThiopurine S-methyltransferase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKd: 1.00E+4nMAssay Description:Binding affinity to thiopurine methyltransferase (unknown origin) by NMR analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
University Park
Curated by ChEMBL
University Park
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of GST-fused human recombinant SET7 after 90 mins by SDS-PAGE based scintillation countingMore data for this Ligand-Target Pair
3D Structure (crystal)TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of EHMT2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of EHMT1 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
University Of Science And Technology Of China
Curated by ChEMBL
University Of Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 3.37E+4nMAssay Description:Inhibition of recombinant human His6-SUMO tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) using oligonucleosome as substrate...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataIC50: 2.84E+4nMAssay Description:Inhibition of EHMT1 (unknown origin) preincubated for 5 mins followed by SAM and biotinylated H3K9 peptide addition measured after 120 mins by HTRF a...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataIC50: 3.01E+4nMAssay Description:Inhibition of EHMT2 (unknown origin) preincubated for 15 mins followed by SAM and biotinylated H3K9 peptide addition measured after 30 mins by TR-FRE...More data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of wild-type human full length NNMT expressed in Escherichia coli BL21(DE3) cells assessed as reduction in 1-methyl-nicotinamide formation...More data for this Ligand-Target Pair
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of Zika virus MTase (4 to 278 residues) expressed in Escherichia coli T7 using GpppAC4 as substrate in presence of [3H]SAM incubated for 3...More data for this Ligand-Target Pair
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of Zika virus MTase (4 to 278 residues) expressed in Escherichia coli T7 using A27 RNA as substrate in presence of [3H]SAM incubated for 3...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan
Curated by ChEMBL
University Of Jinan
Curated by ChEMBL
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of full-length N-terminal FLAG-tagged PRMT5 (unknown origin) (1 to 637 residues) expressed in baculovirus infected Sf9 insect cells using ...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of Dengue virus ribose 2'-O methyltransferase using RNA substrate after 20 mins in presence of [methyl-3H]-AdoMet by microbeta counting an...More data for this Ligand-Target Pair
Affinity DataIC50: <50nMAssay Description:Inhibition of N-terminal His6-tagged human RNA-N7 MTase expressed in Escherichia coli using GpppAC4 and [3H]SAM as substrate preincubated with enzyme...More data for this Ligand-Target Pair
Affinity DataIC50: 0.550nMAssay Description:Inhibition of human guanine-N7 methyltransferase expressed in Saccharomyces cerevisiae YBS40 (MATa leu2 ade2 trp1 his3 ura3 can1 abd1::hisGp360-ABD1)More data for this Ligand-Target Pair
Affinity DataIC50: <50nMAssay Description:Inhibition of N-terminus hexa-histidine tagged-human guanine-N7 methyltransferase expressed in Escherichia coli using GpppAC4 RNA as substrate incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 278nMAssay Description:The transfer of tritiated methyl from [3H] SAM onto RNA substrate was monitored by filter-binding assay, performed according to the method described ...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Montpellier
University Of Montpellier
Affinity DataIC50: 360nMAssay Description:The transfer of tritiated methyl from [3H] SAM onto RNA substrate was monitored by filter-binding assay, performed according to the method described ...More data for this Ligand-Target Pair
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute Of Organic Synthesis
Curated by ChEMBL
Latvian Institute Of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 3.16E+5nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair
TargetIndolethylamine N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center
Curated by ChEMBL
Shionogi Pharmaceutical Research Center
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant INMT (1 to 263 residues) expressed in Escherichia coli BL21 (DE3) cells using S-(5...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of NNMT in HEK293 cells measured after 20 to 24 hrs by RapidFire Mass SpectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) cells using S-ad...More data for this Ligand-Target Pair
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataKd: 7.50E+3nMAssay Description:Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as dissociation constant...More data for this Ligand-Target Pair
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS by isothermal titration calorimetry ass...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of MTase activity of SARS-CoV-2 NSP14 expressed in Escherichia coli BL21(DE3) using GpppA and SAM as substrate preincubated for 15 mins fo...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataIC50: 5.13E+5nMAssay Description:Inhibition of methyltransferase activity of EHMT1 (unknown origin)-mediated dimethylation of a biotinylated histone H3 peptide at lysine-9 by FRET-ba...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataIC50: 5.09E+5nMAssay Description:Inhibition of methyltransferase activity of EHMT2 (unknown origin)-mediated dimethylation of a biotinylated histone H3 peptide at lysine-9 by FRET-ba...More data for this Ligand-Target Pair