BDBM50383376 CHEMBL2030558::CHEMBL2069945::US10544104, Compound 144::US9765037, Compound 144

SMILES COc1ccc(cc1C)-c1nn(CC2CCNCC2)c2ncnc(N)c12

InChI Key InChIKey=MQULVMDBNSSIMR-UHFFFAOYSA-N

Data  2 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50383376   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50383376(CHEMBL2030558 | CHEMBL2069945 | US10544104, Compou...)
Affinity DataKi:  5.50E+3nMAssay Description:Inhibition of human ABL by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50383376(CHEMBL2030558 | CHEMBL2069945 | US10544104, Compou...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human SRC by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50383376(CHEMBL2030558 | CHEMBL2069945 | US10544104, Compou...)
Affinity DataIC50:  5.98E+3nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50383376(CHEMBL2030558 | CHEMBL2069945 | US10544104, Compou...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50383376(CHEMBL2030558 | CHEMBL2069945 | US10544104, Compou...)
Affinity DataIC50:  5.98E+3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50383376(CHEMBL2030558 | CHEMBL2069945 | US10544104, Compou...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphorimaging methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50383376(CHEMBL2030558 | CHEMBL2069945 | US10544104, Compou...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent