BDBM50386381 Nucynta::TAPENTADOL HYDROCHLORIDE::Tapentadol

SMILES CC[C@H]([C@@H](C)CN(C)C)c1cccc(O)c1

InChI Key InChIKey=KWTWDQCKEHXFFR-SMDDNHRTSA-N

Data  1 KI  1 IC50  1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50386381   

TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386381(Nucynta | TAPENTADOL HYDROCHLORIDE | Tapentadol)
Show SMILES CC[C@H]([C@@H](C)CN(C)C)c1cccc(O)c1
Show InChI InChI=1S/C14H23NO/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12/h6-9,11,14,16H,5,10H2,1-4H3/t11-,14+/m0/s1
Affinity DataKi:  160nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK-293 cells by scintillation countingMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University Medicine Greifswald

Curated by ChEMBL
LigandPNGBDBM50386381(Nucynta | TAPENTADOL HYDROCHLORIDE | Tapentadol)
Show SMILES CC[C@H]([C@@H](C)CN(C)C)c1cccc(O)c1
Show InChI InChI=1S/C14H23NO/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12/h6-9,11,14,16H,5,10H2,1-4H3/t11-,14+/m0/s1
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386381(Nucynta | TAPENTADOL HYDROCHLORIDE | Tapentadol)
Show SMILES CC[C@H]([C@@H](C)CN(C)C)c1cccc(O)c1
Show InChI InChI=1S/C14H23NO/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12/h6-9,11,14,16H,5,10H2,1-4H3/t11-,14+/m0/s1
Affinity DataEC50:  670nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF ...More data for this Ligand-Target Pair