BDBM50388189 CHEMBL2057918

SMILES CN1CCN(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cccc(c2CO)-n2ccc3cc(cc(F)c3c2=O)C2CC2)nc1

InChI Key InChIKey=ZTUJNJAKTLHBEX-UHFFFAOYSA-N

Data  20 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50388189   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  27nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction in IgM-induced calcium influx incubated for 20 mins by Fluo-4 dye based fluorescence ass...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of human YES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  27nMAssay Description:Inhibition of BTK in human Ramos cells after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  13nMAssay Description:Inhibition of BTK (unknown origin) after 1 hr by TR-FRET analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  0.300nMAssay Description:Competitive inhibition of BTK by TR-FRET based competitive assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  27nMAssay Description:Inhibition of BTK in human Ramos cells assessed as inhibition of anti human IgM-induced calcium influx preincubated for 20 mins in dark followed by a...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus using biotin labeled peptide substrate after 1 hr by HRTF kinase/...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  4nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Shaanxi University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  64nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSTE20-like serine/threonine-protein kinase(Homo sapiens (Human))
Shaanxi University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  43nMAssay Description:Inhibition of SLK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  7nMAssay Description:Inhibition of BTK (unknown origin) assessed as reduction in TNF productionMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  26nMAssay Description:Inhibition of BTK in human whole bloodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  39nMAssay Description:Inhibition of BTK in human PBMCMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human BTKMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  180nMAssay Description:Inhibition of human FGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  62nMAssay Description:Inhibition of human BMXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Shaanxi University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human TECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  13nMAssay Description:Inhibition of BTK (unknown origin) using biotin-labeled peptide substrate incubated for 1 hr by TR-FRET based HTRF kinase assayMore data for this Ligand-Target Pair