BDBM50389803 AZD7762::CHEMBL2041933

SMILES NC(=O)Nc1cc(sc1C(=O)N[C@H]1CCCNC1)-c1cccc(F)c1

InChI Key InChIKey=IAYGCINLNONXHY-LBPRGKRZSA-N

Data  8 IC50  2 EC50

PDB links: 4 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50389803   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1 [547-977](Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50389803(AZD7762 | CHEMBL2041933)
Affinity DataIC50:  650nMpH: 7.5Assay Description:Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389803(AZD7762 | CHEMBL2041933)
Affinity DataEC50:  280nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as check point abrogationMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389803(AZD7762 | CHEMBL2041933)
Affinity DataEC50:  10nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of campothecin induced check pointMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389803(AZD7762 | CHEMBL2041933)
Affinity DataIC50: <10nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389803(AZD7762 | CHEMBL2041933)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389803(AZD7762 | CHEMBL2041933)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of Chk1 (unknown origin) by luminescent ADP-Glo assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389803(AZD7762 | CHEMBL2041933)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389803(AZD7762 | CHEMBL2041933)
Affinity DataIC50:  5nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389803(AZD7762 | CHEMBL2041933)
Affinity DataIC50:  6nMAssay Description:Inhibition of CHK1 (unknown origin) using Cdc25 peptide as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mi...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389803(AZD7762 | CHEMBL2041933)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant CHK1 expressed in insect cells using biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR as substrate after 2 hrs by scintill...More data for this Ligand-Target Pair