BDBM50391358 CHEMBL2147989

SMILES Clc1cccc(c1)-c1c[nH]nn1

InChI Key InChIKey=VLAULFMSWJFSFA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50391358   

TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
Ludwig Center For Cancer Research Of The University Of Lausanne

Curated by ChEMBL
LigandPNGBDBM50391358(CHEMBL2147989)
Affinity DataIC50:  20nMAssay Description:Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Ludwig Center For Cancer Research Of The University Of Lausanne

Curated by ChEMBL
LigandPNGBDBM50391358(CHEMBL2147989)
Affinity DataIC50:  620nMAssay Description:Inhibition of human IDO1 transfected in mouse P815B clone-6 cells by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Ludwig Center For Cancer Research Of The University Of Lausanne

Curated by ChEMBL
LigandPNGBDBM50391358(CHEMBL2147989)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human TDO transfected in mouse P815B clone 19 cells by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Ludwig Center For Cancer Research Of The University Of Lausanne

Curated by ChEMBL
LigandPNGBDBM50391358(CHEMBL2147989)
Affinity DataIC50:  620nMAssay Description:Inhibition of human IDO1 expressed in HEK293T cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 7 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Ludwig Center For Cancer Research Of The University Of Lausanne

Curated by ChEMBL
LigandPNGBDBM50391358(CHEMBL2147989)
Affinity DataIC50:  1.20E+3nMpH: 6.5Assay Description:Inhibition of human recombinant N-terminal His-tagged IDO1 (Ala2 to Gly403) overexpressed in Escherichia coli BL21 at pH 6.5 after 60 mins by HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Ludwig Center For Cancer Research Of The University Of Lausanne

Curated by ChEMBL
LigandPNGBDBM50391358(CHEMBL2147989)
Affinity DataIC50:  350nMAssay Description:Inhibition of recombinant human IDO1 expressed in Escherichia coli Rosetta (DE3) cells assessed as reduction in kynurenine production using L-tryptop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
Ludwig Center For Cancer Research Of The University Of Lausanne

Curated by ChEMBL
LigandPNGBDBM50391358(CHEMBL2147989)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed