BDBM50393245 CHEMBL2151439

SMILES O=C(N[C@@H]1CN2CCC1CC2)c1n[nH]c2ccccc12

InChI Key InChIKey=TXCYUSKWBHUVEP-CYBMUJFWSA-N

Data  3 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50393245   

Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataKi:  2nMAssay Description:Inhibition of 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataKi:  6nMAssay Description:Binding affinity to human alpha7 nAchRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-MLA from alpha7 nAChR in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Macaca mulatta)
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataEC50:  400nMAssay Description:Agonist activity at wild type monkey alpha7 nAChR by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataIC50:  32.7nMAssay Description:Antagonist activity at 5HT3 receptor expressed in N1E115 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataEC50:  7.70E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in QM7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at 5HT3 receptor expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed