BDBM50394892 CHEMBL2165051

SMILES Cc1ncnc(n1)-n1c(Nc2cccc(O)c2)nc2ccccc12

InChI Key InChIKey=HQPMEVMEMPHSDM-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50394892   

LigandPNGBDBM50394892(CHEMBL2165051)
Affinity DataKi:  2nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50394892(CHEMBL2165051)
Affinity DataKi:  3nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50394892(CHEMBL2165051)
Affinity DataKi:  4nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50394892(CHEMBL2165051)
Affinity DataKi:  4nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50394892(CHEMBL2165051)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed