BDBM50397360 CHEMBL2170177::US10188756, Compound CN110
SMILES COc1ccc(Cn2ccc3ccc(cc23)C(=O)NO)cc1
InChI Key InChIKey=AJRGHIGYPXNABY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 92 hits for monomerid = 50397360
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of HDAC6 (unknown origin) after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 (unknown origin) after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of human KDAC8 preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibition of human KDAC6 preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human KDAC3 preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of human KDAC1 preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of recombinant human HDAC8 using Fluor de Lys as substrate preincubated for 90 mins followed by BML-KI176 addition measured after 45 mins ...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Schistosoma mansoni)
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 436nMAssay Description:Inhibition of recombinant Schistosoma mansoni HDAC8 expressed in Escherichia coli using Fluor de Lys as substrate preincubated for 90 mins followed b...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant HDAC8 using fluor de Lys as substrate preincubated for 5 mins followed by substrate addition measured after 25 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of HDAC6 by fluorometric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC4 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of HDAC8 by fluorometric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC2 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC1 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.74E+3nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Affinity DataIC50: >7.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Affinity DataIC50: 7.39E+3nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Affinity DataIC50: >7.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Affinity DataIC50: 18.3nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Affinity DataIC50: >7.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Schistosoma mansoni)
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 9.33E+7nMAssay Description:Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of HDAC10 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by su...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HDAC2 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HDAC3 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of HDAC6 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HDAC2 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HDAC3 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of HDAC6 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of HDAC10 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC7 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.82E+4nMAssay Description:Inhibition of recombinant human full length HDAC6 expressed in fall armyworm Sf9 cells using fluorogenic ZMAL as substrate after 90 mins by fluorimet...More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in Escherichia coli BL21(DE3) using fluor de Lys(R) as substrate af...More data for this Ligand-Target Pair
Affinity DataIC50: 2.83E+4nMAssay Description:Inhibition of recombinant human full length C-terminal FLAG-tagged HDAC1 expressed in fall armyworm Sf9 cells using fluorogenic ZMAL as substrate aft...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Schistosoma mansoni)
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 436nMAssay Description:Inhibition of Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluoro...More data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorome...More data for this Ligand-Target Pair
Affinity DataIC50: 2.83E+4nMAssay Description:Inhibition of C-terminal FLAG/His-tagged full length human HDAC1 expressed in baculovirus infected Sf9 insect cells using Z(Ac)Lys-AMC as substrate b...More data for this Ligand-Target Pair
Affinity DataIC50: 4.82E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus infected Sf9 insect cells using Z(Ac)Lys-AMC as substrate by flu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 mL6/L179I mutant expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as subs...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 mL1/mL6/L179I mutant expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as ...More data for this Ligand-Target Pair
Affinity DataKd: 75nMAssay Description:Binding affinity to human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells by ITC methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Schistosoma mansoni)
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Affinity DataKd: 367nMAssay Description:Binding affinity to Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells by ITC methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of recombinant full-length human C-terminal FLAG-His-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using Boc-L-Lys(Ac)-A...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
University Of Illinois At Chicago
Curated by ChEMBL
University Of Illinois At Chicago
Curated by ChEMBL
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of recombinant human full-length C-terminal His-tagged HDAC3 (395 to 489 residues)/human NCOR2 expressed in baculovirus infected Sf9 insec...More data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of recombinant HDAC8 (unknown origin) expressed in Escherichia coli using fluor de Lys(R) as substrate pretreated for 5 mins followed by s...More data for this Ligand-Target Pair