BDBM50397745 CHEMBL2177161
SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1cccnc1
InChI Key InChIKey=FHCSBLWRGCOVPT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50397745
Affinity DataKi: 4.90nMAssay Description:Inhibition of human recombinant GSK3beta using biotin- AAEELDSRAGS(PO3H2)PQL as substrate and [gamma32P]ATP after 20 mins by scintillation proximity ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 4.90nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKon: 0.0193M-1s-1Assay Description:Binding affinity to recombinant GSK3beta (unknown origin) assessed as dissociation rate constant upto 0.00975 uM by SPR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 76nMAssay Description:Inhibition of GSK3beta-mediated Tau phosphorylation in mouse 3T3 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair