BDBM50400511 CHEMBL2203406
SMILES CCCN(CC[C@]1(O)C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
InChI Key InChIKey=QXYZJXCNTMMWEO-BERHBOFZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 50400511
Affinity DataKi: 0.5nMAssay Description:Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 3.61nMAssay Description:Displacement of [3H]YM-09151-2 from human cloned dopamine D3 receptor expressed in CHOp cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 5.60nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 21nMAssay Description:Displacement of [3H]-methylspiperon from human D2RL expressed in HEK293 cell membranes measured after 90 mins by topcount assayMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Displacement of [3H]-N-methylspiperone from D3 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 32nMAssay Description:Displacement of [3H]-citalopram from human SERT receptor expressed in stable HEK cell membranes after 90 mins by microbeta scintillation counting met...More data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 45nMAssay Description:Displacement of [3H]-N-methylspiperone from recombinant human D4 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta ...More data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 110nMAssay Description:Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in stable HEK cell membranes after 90 mins by microbeta scintillation coun...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 205nMAssay Description:Displacement of [3H]-Win35428 from human DAT expressed in stable HEK cell membranes after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 224nMAssay Description:Displacement of [125I]-Iodo-aminopotentidine from human histamine H2 receptor expressed in stable HEK cell membranes after 90 mins by microbeta scint...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 436nMAssay Description:Displacement of [3H]-Nisoxetine from human NET receptor expressed in stable HEK cell membranes after 90 mins by microbeta scintillation counting meth...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 531nMAssay Description:Displacement of [3H]-pentazocine from sigma1 receptor (unknown origin) after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 666nMAssay Description:Displacement of [3H]-prazosin from recombinant human alpha1B adrenergic receptor transiently expressed in HEKT cell membranes measured after 90 mins ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 708nMAssay Description:Displacement of [3H]-Way100635 from recombinant human 5HT1A receptor stably expressed in CHO cell membranes measured after 90 mins by microbeta scint...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 745nMAssay Description:Displacement of [3H]-DAMGO from recombinant human MOR stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counti...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 762nMAssay Description:Displacement of [3H]-Mesulergine from recombinant human 5HT2C receptor expressed in HEK cell membranes measured after 90 mins by microbeta scintillat...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 770nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 893nMAssay Description:Displacement of [3H]-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK Flp-In cell membranes measured after 90 mins...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 1.18E+3nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 1.18E+3nMAssay Description:Displacement of [3H]-prazosin from recombinant human alpha1D adrenergic receptor measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 2.28E+3nMAssay Description:Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M4 receptor expressed in stable CHO cell membranes after 90 mins by microbeta scintillation c...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 2.30E+3nMAssay Description:Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M5 receptor expressed in stable CHO cell membranes after 90 mins by microbeta scintillation c...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 2.84E+3nMAssay Description:Displacement of [3H]-Ketanserin from 5HT2A receptor (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: 3.90E+3nMAssay Description:Displacement of [3H]-N-methylspiperone from recombinant human D2 receptor stably expressed in fibroblast cell membranes measured after 90 mins by mic...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: >4.00E+3nMAssay Description:Displacement of [3H]YM-09151-2 from human cloned dopamine D2 receptor expressed in CHOp cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
National Institute Of Neurological Disorders And Stroke
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-U69593 from KOR (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinopirole-induced mitogenisis after 24 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: 9.30nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair