BDBM50400783 CHEMBL1608462

SMILES CC(C)n1ncc2c(cc(nc12)C1CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key InChIKey=HNHUNRACMOTTER-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50400783   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50400783(CHEMBL1608462)
Affinity DataKi:  700nMAssay Description:Inhibition of human FLAG-tev-fused EZH2 expressed in baculovirus infected Sf9 insect cells using H3K27 peptide as substrate in presence of [3H]-SAM b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50400783(CHEMBL1608462)
Affinity DataKi:  700nMAssay Description:Non-competitive inhibition of human EZH2 using [3H]-SAM as substrate in presence of H3K27AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50400783(CHEMBL1608462)
Affinity DataKi:  700nMAssay Description:Competitive inhibition of human EZH2 using H3K27A as substrate in presence of SAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50400783(CHEMBL1608462)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human EZH2 (2 to 746 residues) expressed in baculovirus infected insect cells using histone H3 as substrate preincubated for 10 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50400783(CHEMBL1608462)
Affinity DataIC50:  3.40E+3nMAssay Description:Displacement of [3H]-SAM from N-terminal FLAG-tev-tagged human EZH2 expressed in baculovirus infected insect cells by liquid scintillation counter me...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50400783(CHEMBL1608462)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed