BDBM50405521 ALO 1401-02::ALO-1401-02::BETAXOLOL HYDROCHLORIDE::Betaxolol

SMILES CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1

InChI Key InChIKey=NWIUTZDMDHAVTP-UHFFFAOYSA-N

Data  3 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50405521   

TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405521(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
Affinity DataIC50:  37nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBeta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50405521(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
Affinity DataIC50:  657nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50405521(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
Affinity DataKd:  105nMAssay Description:In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50405521(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50405521(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
Affinity DataKd:  1.86E+5nMAssay Description:Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50405521(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
Affinity DataKd:  93nMAssay Description:Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50405521(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
Affinity DataKd:  1.70nMAssay Description:In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed