BDBM50412114 CHEMBL183460::SB-649915
SMILES Cc1ccc2c(OCCN3CCC(Cc4ccc5OCC(=O)Nc5c4)CC3)cccc2n1
InChI Key InChIKey=PJSUYRBCBFPCQW-UHFFFAOYSA-N
Data 30 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50412114
Affinity DataKi: 0.316nMAssay Description:Mean negative logarithim of binding affinity was measured for the human 5-hydroxytryptamine 1A receptor; n>/=3More data for this Ligand-Target Pair
Affinity DataKi: 0.316nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.320nMAssay Description:Negative logarithm causing 50% receptor occupancy against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.58nMAssay Description:Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT1D receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]WAY100635 from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]WAY-100635 from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]WAY-100635 from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.51nMAssay Description:Displacement of [3H]5HT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Inhibition of [3H]5-HT binding to serotonin transporter in rat cortical synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 6.30nMAssay Description:Mean negative logarithim of binding affinity was measured for the rat serotonin transporter; n>/=3More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataKi: 6.30nMAssay Description:Negative logarithm causing 50% receptor occupancy against serotonin transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 7.90nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat cortical synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 7.94nMAssay Description:Inhibition of [3H]5HT reuptake at SERT in rat cortical synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of [3H]5HT from human cloned 5HT1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Inhibition of [3H]5HT uptake at SERT in rat cortical synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT1B receptorMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of [3H]5-HT from human cloned 5HT1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: <501nMAssay Description:Negative logarithm causing 50% receptor occupancy against beta-2 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 631nMAssay Description:Displacement of [125I]iodosulpiride from human cloned D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.26E+3nMAssay Description:Displacement of [125I]iodosulpiride from human cloned D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.59E+3nMAssay Description:Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.51E+3nMAssay Description:Binding affinity at adrenergic beta 1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.16E+3nMAssay Description:Displacement of [3H]ketanserin from human cloned 5HT2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: <7.94E+3nMAssay Description:Displacement of [3H]mesulergine from human cloned 5HT2C receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in HeLa cellsMore data for this Ligand-Target Pair