BDBM50414962 CHEMBL566759

SMILES CC(=C)COc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1ccncc1

InChI Key InChIKey=DHSWMQRDIKTONS-UHFFFAOYSA-N

Data  3 IC50

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50414962   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414962(CHEMBL566759)
Show SMILES CC(=C)COc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1ccncc1
Show InChI InChI=1S/C26H33N3O2/c1-21(2)20-31-24-6-4-3-5-23(24)19-28-15-9-26(10-16-28)11-17-29(18-12-26)25(30)22-7-13-27-14-8-22/h3-8,13-14H,1,9-12,15-20H2,2H3
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414962(CHEMBL566759)
Show SMILES CC(=C)COc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1ccncc1
Show InChI InChI=1S/C26H33N3O2/c1-21(2)20-31-24-6-4-3-5-23(24)19-28-15-9-26(10-16-28)11-17-29(18-12-26)25(30)22-7-13-27-14-8-22/h3-8,13-14H,1,9-12,15-20H2,2H3
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiologyMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414962(CHEMBL566759)
Show SMILES CC(=C)COc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1ccncc1
Show InChI InChI=1S/C26H33N3O2/c1-21(2)20-31-24-6-4-3-5-23(24)19-28-15-9-26(10-16-28)11-17-29(18-12-26)25(30)22-7-13-27-14-8-22/h3-8,13-14H,1,9-12,15-20H2,2H3
Affinity DataIC50: 70.8nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair