BDBM50415427 CHEMBL601218

SMILES Cc1onc(c1C(=O)N1CCc2cc(Cl)ccc12)-c1ccccc1Cl

InChI Key InChIKey=CZTXMHXBVNZMDI-UHFFFAOYSA-N

Data  1 EC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50415427   

TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50415427(CHEMBL601218)
Show SMILES Cc1onc(c1C(=O)N1CCc2cc(Cl)ccc12)-c1ccccc1Cl
Show InChI InChI=1S/C19H14Cl2N2O2/c1-11-17(18(22-25-11)14-4-2-3-5-15(14)21)19(24)23-9-8-12-10-13(20)6-7-16(12)23/h2-7,10H,8-9H2,1H3
Affinity DataEC50:  3.16E+3nMAssay Description:Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase rep...More data for this Ligand-Target Pair