BDBM50416275 CHEMBL1083341

SMILES Cc1ccc(s1)C(=O)N1CCCC1c1nc(no1)-c1cccc(Cl)c1

InChI Key InChIKey=ABWONHBWGCZVOP-UHFFFAOYSA-N

Data  1 KI  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50416275   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter Plc

Curated by ChEMBL
LigandPNGBDBM50416275(CHEMBL1083341)
Show SMILES Cc1ccc(s1)C(=O)N1CCCC1c1nc(no1)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H16ClN3O2S/c1-11-7-8-15(25-11)18(23)22-9-3-6-14(22)17-20-16(21-24-17)12-4-2-5-13(19)10-12/h2,4-5,7-8,10,14H,3,6,9H2,1H3
Affinity DataKi:  123nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter Plc

Curated by ChEMBL
LigandPNGBDBM50416275(CHEMBL1083341)
Show SMILES Cc1ccc(s1)C(=O)N1CCCC1c1nc(no1)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H16ClN3O2S/c1-11-7-8-15(25-11)18(23)22-9-3-6-14(22)17-20-16(21-24-17)12-4-2-5-13(19)10-12/h2,4-5,7-8,10,14H,3,6,9H2,1H3
Affinity DataIC50: 6.61E+3nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair