BDBM50418088 7-ETHYL-10-HYDROXY-CAMPTOTHECIN

SMILES CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(O)cc12

InChI Key InChIKey=FJHBVJOVLFPMQE-QFIPXVFZSA-N

Data  1 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50418088   

TargetCytochrome P450 3A4(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50418088(7-ETHYL-10-HYDROXY-CAMPTOTHECIN)
Affinity DataKi:  2.60E+4nMAssay Description:Mechanism based inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50418088(7-ETHYL-10-HYDROXY-CAMPTOTHECIN)
Affinity DataIC50:  176nMAssay Description:TP_TRANSPORTER: drug resistance(Imatinib mesylate) in BCRP-expressing SaoS2 cellsMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Human)
National Chiayi University

Curated by ChEMBL
LigandPNGBDBM50418088(7-ETHYL-10-HYDROXY-CAMPTOTHECIN)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human topoisomerase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50418088(7-ETHYL-10-HYDROXY-CAMPTOTHECIN)
Affinity DataIC50:  3.60E+5nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed