BDBM50425123 CHEMBL2313234::US9669035, B-3
SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl
InChI Key InChIKey=LZRGPVBUCASWQB-UHFFFAOYSA-N
Data 15 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50425123
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant PDE5A expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Pharmaceutica
Curated by ChEMBL
Janssen Pharmaceutica
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: 2.30nMpH: 7.8 T: 2°CAssay Description:Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Pharmaceutica
Curated by ChEMBL
Janssen Pharmaceutica
Curated by ChEMBL
Affinity DataIC50: 34nMpH: 7.8 T: 2°CAssay Description:Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Pharmaceutica
Curated by ChEMBL
Janssen Pharmaceutica
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant PDE3B expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant PDE11A expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of human recombinant PDE7A expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant PDE4A expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: 7.76E+3nMAssay Description:Inhibition of human recombinant PDE3A expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human recombinant PDE1B expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair