BDBM50425863 CHEMBL2312652

SMILES CN1CCC(CC1)NC(=O)c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1N[C@@H]1COC[C@H]1O

InChI Key InChIKey=PIKLKDCPFVVYDK-QZTJIDSGSA-N

Data  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50425863   

TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of PAK4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CDK6/cyclin D3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of NEK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  2.49E+4nMAssay Description:Inhibition of MYLK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of MST2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 26(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of MASK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase MARK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of MARK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of MAPKAP-K2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of MAPK1/ERK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  2.48E+3nMAssay Description:Inhibition of MAP4K4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  1.34E+4nMAssay Description:Inhibition of MAP3K9 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.68E+3nMAssay Description:Inhibition of LCK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of INSR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of IKKi (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of IKK-beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of GSK3-beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of ECK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of CLK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of CK1-delta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CHK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CAMK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of BTK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of Aurora-A (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of ABL (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of P-selectin aggregation in platelet surface (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  10nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed