BDBM504263 (R)-N-(2-(2-Fluoro-3-hydroxy-3- methylbutyl)-6-(4- isopropylpiperazin-1-yl)-1- oxoisoindolin-5-yl)pyrazolo[1,5- a]pyrimidine-3-carboxamide::US11034698, Example 113

SMILES CC(C)N1CCN(CC1)c1cc2C(=O)N(C[C@@H](F)C(C)(C)O)Cc2cc1NC(=O)c1cnn2cccnc12

InChI Key InChIKey=IDMBQRMXJOSFAK-HSZRJFAPSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504263   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM504263((R)-N-(2-(2-Fluoro-3-hydroxy-3- methylbutyl)-6-(4-...)
Affinity DataKi:  7.5nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent