BDBM50427363 CHEMBL2326002
SMILES CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1Cl
InChI Key InChIKey=HXWARSZQGAFXJM-MGPUTAFESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50427363
Affinity DataKi: 0.0800nMAssay Description:Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of PKC epsilon (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Inhibition of PKC eta (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Inhibition of PKC beta1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of PKC delta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 15 mins by spectrophotometry in presence of ATPMore data for this Ligand-Target Pair
Affinity DataKi: 356nMAssay Description:Inhibition of PKC alpha (unknown origin) using RRRRRKGSFKRKA as substrate after 15 mins by spectrophotometry in presence of ATPMore data for this Ligand-Target Pair
Affinity DataKi: 393nMAssay Description:Inhibition of PKC beta2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 725nMAssay Description:Inhibition of PKC gamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of Zap70 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of Itk (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of Erk-1 (unknown origin)More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of c-Raf (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of Lyn (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of Fyn (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 2.42E+3nMAssay Description:Inhibition of PKC mu (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of PKC zeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...More data for this Ligand-Target Pair