BDBM504281 (5S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phenyl]-1′-methyl-spiro[7,8-dihydro-6H-quinazoline-5,6′-hexahydropyrimidine]-2′,4′-dione::US11034699, Example 7

SMILES: CN1C(=O)N(C(=O)C[C@]11CCCc2ncncc12)c1c(F)cc(cc1F)C#Cc1ccccc1

InChI Key: InChIKey=CMFHEUJVSQXEFR-SANMLTNESA-N

Data: 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504281   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM504281 ((5S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phe...) Show SMILES CN1C(=O)N(C(=O)C[C@]11CCCc2ncncc12)c1c(F)cc(cc1F)C#Cc1ccccc1 Show InChI InChI=1S/C26H20F2N4O2/c1-31-25(34)32(23(33)14-26(31)11-5-8-22-19(26)15-29-16-30-22)24-20(27)12-18(13-21(24)28)10-9-17-6-3-2-4-7-17/h2-4,6-7,12-13,15-16H,5,8,11,14H2,1H3/t26-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	65	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...				US Patent US11034699 (2021)
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