BindingDB logo
myBDB logout

BDBM504281 (5S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phenyl]-1′-methyl-spiro[7,8-dihydro-6H-quinazoline-5,6′-hexahydropyrimidine]-2′,4′-dione::US11034699, Example 7

SMILES: CN1C(=O)N(C(=O)C[C@]11CCCc2ncncc12)c1c(F)cc(cc1F)C#Cc1ccccc1

InChI Key: InChIKey=CMFHEUJVSQXEFR-SANMLTNESA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504281   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM504281
PNG
((5S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phe...)
Show SMILES CN1C(=O)N(C(=O)C[C@]11CCCc2ncncc12)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H20F2N4O2/c1-31-25(34)32(23(33)14-26(31)11-5-8-22-19(26)15-29-16-30-22)24-20(27)12-18(13-21(24)28)10-9-17-6-3-2-4-7-17/h2-4,6-7,12-13,15-16H,5,8,11,14H2,1H3/t26-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 65n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US11034699 (2021)

More data for this
Ligand-Target Pair