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BDBM504288 (4S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phenyl]-1,1′-dimethyl-spiro[6,7-dihydro-5H-indazole-4,6′-hexahydropyrimidine]-2′,4′-dione::US11034699, Example 14

SMILES: CN1C(=O)N(C(=O)C[C@]11CCCc2c1ccn2C)c1c(F)cc(cc1F)C#Cc1ccccc1

InChI Key: InChIKey=RDYFWSWITUAFNE-MHZLTWQESA-N

Data: 1 EC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504288   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM504288
PNG
((4S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phe...)
Show SMILES CN1C(=O)N(C(=O)C[C@]11CCCc2c1ccn2C)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H23F2N3O2/c1-30-14-12-20-23(30)9-6-13-27(20)17-24(33)32(26(34)31(27)2)25-21(28)15-19(16-22(25)29)11-10-18-7-4-3-5-8-18/h3-5,7-8,12,14-16H,6,9,13,17H2,1-2H3/t27-/m0/s1
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US Patent
n/an/an/an/a 75n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US11034699 (2021)

More data for this
Ligand-Target Pair