BDBM504289 (4S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phenyl]-1′-methyl-spiro[5,6,7,8-tetrahydro-1H-cyclohepta[c]pyrazole-4,6′-hexahydropyrimidine]-2′,4′-dione::US11034699, Example 15

SMILES: CN1C(=O)N(C(=O)C[C@]11CCCCc2[nH]ncc12)c1c(F)cc(cc1F)C#Cc1ccccc1

InChI Key:

Data: 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504289   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM504289 ((4S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phe...) Show SMILES CN1C(=O)N(C(=O)C[C@]11CCCCc2[nH]ncc12)c1c(F)cc(cc1F)C#Cc1ccccc1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	54	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...				US Patent US11034699 (2021)
					More data for this Ligand-Target Pair