BDBM50430056 CHEMBL2336409::SGI-1027
SMILES Cc1cc(Nc2ccc(NC(=O)c3ccc(Nc4ccnc5ccccc45)cc3)cc2)nc(N)n1
InChI Key InChIKey=QSYLKMKIVWJAAK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50430056
Affinity DataIC50: 1.60E+3nMpH: 7.5Assay Description:Assays (0.1 ml) were conducted in 96-well black half-area plates in either a Wallac VICTOR2 or Biotek Synergy Neo plate reader at 37 °C in 10 mM Tri...More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 3A(Homo sapiens (Human))
M. V. Lomonosov Moscow State University
Curated by ChEMBL
M. V. Lomonosov Moscow State University
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of human C-terminal DNMT3A (623 to 908 residues) using 5'-biotin labeled oligonucleotide as substrate measured after 1 hrMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 3A(Homo sapiens (Human))
M. V. Lomonosov Moscow State University
Curated by ChEMBL
M. V. Lomonosov Moscow State University
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of His6-tagged human recombinant DNMT3a expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-bio...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biot...More data for this Ligand-Target Pair
Affinity DataEC50: 1.02E+4nMAssay Description:Inhibition of human His-DNMT1 using [methyl-3H]SAM as substrate after 2 hrsMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 3A(Homo sapiens (Human))
M. V. Lomonosov Moscow State University
Curated by ChEMBL
M. V. Lomonosov Moscow State University
Curated by ChEMBL
Affinity DataEC50: 900nMAssay Description:Inhibition of human C-terminal DNMT3A after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of human GLP (734 to 1235) using histone as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by liqu...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Rattus norvegicus)
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 1.39E+5nMAssay Description:Inhibition of rat recombinant PRMT1 using histone as substrate preincubated for 5 mins followed by substrate addition measured after 6.5 mins by liqu...More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 3-like(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DNMT3A2/3L using unmethylated DNA as substrate in presence of [methyl-3H]-AdoMetMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human N-terminal 600 residues-deleted DNMT1 using hemimethylated (GAC)12 as substrate preincubated for 5 mins followed by substrate add...More data for this Ligand-Target Pair
Affinity DataIC50: 850nMAssay Description:Inhibition of human N-terminal 600 residues-deleted DNMT1 using poly(dI-dC) as substrate in presence of AdoMetMore data for this Ligand-Target Pair
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of human DNMT1 using AdoMet and poly dI-dC after 2 hrs by radioactive assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate by radioactive methyl transfer assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.55E+3nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias
Curated by ChEMBL
Universidad De Oviedo-Principado De Asturias
Curated by ChEMBL
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias
Curated by ChEMBL
Universidad De Oviedo-Principado De Asturias
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human DNMT1 using hemimethylated DNA as substrate by radioactive methyl transfer assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of His6-tagged human recombinant DNMT3b expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-bio...More data for this Ligand-Target Pair