BDBM50431074 CHEMBL2338790::US10463663, Example 27::US11129828, Example 27::US9212147, 254::US9290456, 27::US9931340, Example 27

SMILES Oc1cc(CCc2ccc(Cl)cc2)n[nH]c1=O

InChI Key InChIKey=JZILLMBFJMBFQR-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50431074   

TargetD-amino-acid oxidase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431074(CHEMBL2338790 | US10463663, Example 27 | US1112982...)
Affinity DataIC50:  2.70nMpH: 7.5 T: 2°CAssay Description:The DAAO inhibitory activity was measured by assaying the amount of hydrogen peroxide (H2O2) produced by reacting DAAO protein with flavin adenine di...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD-amino-acid oxidase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431074(CHEMBL2338790 | US10463663, Example 27 | US1112982...)
Affinity DataIC50:  6.30nMpH: 7.5 T: 2°CAssay Description:This test was performed by partially modifying the method of Philip et. al. (J. Biomol. Screen. Vol. 11, pp 481-487, 2006). HEK293 cells that stably ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD-amino-acid oxidase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431074(CHEMBL2338790 | US10463663, Example 27 | US1112982...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD-amino-acid oxidase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431074(CHEMBL2338790 | US10463663, Example 27 | US1112982...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431074(CHEMBL2338790 | US10463663, Example 27 | US1112982...)
Affinity DataIC50:  13nMAssay Description:Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50431074(CHEMBL2338790 | US10463663, Example 27 | US1112982...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of rat full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Mus musculus)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50431074(CHEMBL2338790 | US10463663, Example 27 | US1112982...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431074(CHEMBL2338790 | US10463663, Example 27 | US1112982...)
Affinity DataIC50:  13nMAssay Description:Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD-amino-acid oxidase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431074(CHEMBL2338790 | US10463663, Example 27 | US1112982...)
Affinity DataIC50:  13nMAssay Description:The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD-amino-acid oxidase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431074(CHEMBL2338790 | US10463663, Example 27 | US1112982...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed