BDBM504320 US11040968, Example 002::US11136324, Example 3::WX002

SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnc2CCCCn12

InChI Key InChIKey=FLPJKFBHZBJFGH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 504320   

TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM504320(US11040968, Example 002 | US11136324, Example 3 | ...)
Affinity DataIC50:  13.4nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM504320(US11040968, Example 002 | US11136324, Example 3 | ...)
Affinity DataIC50:  5.60nMAssay Description:Primary reaction buffer solution: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOTreatme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent