BDBM50434339 CHEMBL2386761::US9446044, 45

SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4)c3c2s1

InChI Key InChIKey=WYEVMOFRKALLJA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50434339   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434339(CHEMBL2386761 | US9446044, 45)
Affinity DataIC50:  13.1nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434339(CHEMBL2386761 | US9446044, 45)
Affinity DataIC50:  19.2nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434339(CHEMBL2386761 | US9446044, 45)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant DYRK1B (unknown origin) after 120 mins in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
University Of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434339(CHEMBL2386761 | US9446044, 45)
Affinity DataIC50:  200nMAssay Description:Inhibition of GSK3alpha/beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434339(CHEMBL2386761 | US9446044, 45)
Affinity DataIC50:  40nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434339(CHEMBL2386761 | US9446044, 45)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
University Of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434339(CHEMBL2386761 | US9446044, 45)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434339(CHEMBL2386761 | US9446044, 45)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant DYRK1A (unknown origin) after 120 mins in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed