BDBM50434369 METHYLENE BLUE CHLORIDE HYDRATE::Methylene Blue::Methylthionine Chloride::Methylthionine HCl::Methylthioninium Chloride

SMILES CN(C)c1ccc2nc3ccc(cc3sc2c1)=[N+](C)C

InChI Key InChIKey=RBTBFTRPCNLSDE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50434369   

TargetMicrotubule-associated protein tau(Human)
Humboldt Universit£T Zu Berlin

Curated by ChEMBL
LigandPNGBDBM50434369(METHYLENE BLUE CHLORIDE HYDRATE | Methylene Blue |...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of tau protein aggregation (unknown origin) by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrotubule-associated protein tau(Human)
Humboldt Universit£T Zu Berlin

Curated by ChEMBL
LigandPNGBDBM50434369(METHYLENE BLUE CHLORIDE HYDRATE | Methylene Blue |...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human recombinant brain tau protein (412 amino acid residues) filament assembly expressed in Escherichia coli BL21(DE3) by electron mic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50434369(METHYLENE BLUE CHLORIDE HYDRATE | Methylene Blue |...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50434369(METHYLENE BLUE CHLORIDE HYDRATE | Methylene Blue |...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThiosulfate sulfurtransferase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50434369(METHYLENE BLUE CHLORIDE HYDRATE | Methylene Blue |...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target60 kDa heat shock protein, mitochondrial(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50434369(METHYLENE BLUE CHLORIDE HYDRATE | Methylene Blue |...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChaperonin GroEL(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50434369(METHYLENE BLUE CHLORIDE HYDRATE | Methylene Blue |...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed