BDBM504399 (S)-1-(2-(4-(3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)-1-(4-fluorophenyl)ethanamine ::US11040979, Compound 3

SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(Cl)cnn2c1

InChI Key InChIKey=YBLTZZSNMXRWQX-MHZLTWQESA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 504399   

TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM504399((S)-1-(2-(4-(3-chloro-6-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: >100nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit [V560G](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM504399((S)-1-(2-(4-(3-chloro-6-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  55nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM504399((S)-1-(2-(4-(3-chloro-6-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: <1nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit [V559D,V654A](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM504399((S)-1-(2-(4-(3-chloro-6-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: >100nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit [V559D,T670I](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM504399((S)-1-(2-(4-(3-chloro-6-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  5.5nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent