BindingDB BDBM50440018 CHEMBL2425628

BDBM50440018 CHEMBL2425628

SMILES CS(=O)(=O)CCCOc1cccc2n(ccc12)-c1ccnc(N[C@H]2CC[C@@H](CC2)C(=O)N2CCC(O)CC2)n1

InChI Key InChIKey=NXWXUDHOUKWAQU-MEMLXQNLSA-N

Data 34 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50440018

Dual specificity protein kinase TTK(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 1.90E+3nMAssay Description:Binding affinity to TTK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Atypical kinase COQ8A, mitochondrial(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 490nMAssay Description:Binding affinity to ADCK3 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

NUAK family SNF1-like kinase 2(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 2.60E+3nMAssay Description:Binding affinity to SNARK (unknown origin)More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Myosin light chain kinase family member 4(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 620nMAssay Description:Binding affinity to SgK085 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Ribosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 2.10E+3nMAssay Description:Binding affinity to RPS6KA1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Interferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 120nMAssay Description:Binding affinity to PRKR (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Platelet-derived growth factor receptor beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 6.80E+3nMAssay Description:Binding affinity to PDGFRB (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase Nek7(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 6.90E+3nMAssay Description:Binding affinity to NEK7 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase Nek5(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 1.40E+3nMAssay Description:Binding affinity to NEK5 (unknown origin)More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase Nek1(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 4.00E+3nMAssay Description:Binding affinity to NEK1 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 2.10E+3nMAssay Description:Binding affinity to MKNK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Dual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 310nMAssay Description:Binding affinity to MEK6 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Dual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 390nMAssay Description:Binding affinity to MEK4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

LIM domain kinase 2(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 2.80E+3nMAssay Description:Binding affinity to LIMK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

LIM domain kinase 1(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 870nMAssay Description:Binding affinity to LIMK1 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Mitogen-activated protein kinase 15(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 650nMAssay Description:Binding affinity to ERK8 (unknown origin)More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Mitogen-activated protein kinase 7(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 1.50E+3nMAssay Description:Binding affinity to ERK5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Mitogen-activated protein kinase 4(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 1.10E+4nMAssay Description:Binding affinity to ERK4 (unknown origin)More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Mitogen-activated protein kinase 6(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 330nMAssay Description:Binding affinity to ERK3 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 1.50E+3nMAssay Description:Binding affinity to ERK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase 17A(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 440nMAssay Description:Binding affinity to DRAK1 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase DCLK3(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 1.80E+3nMAssay Description:Binding affinity to DCAMKL3 (unknown origin)More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Death-associated protein kinase 3(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 880nMAssay Description:Binding affinity to DAPK3 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Death-associated protein kinase 2(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 1.30E+3nMAssay Description:Binding affinity to DAPK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Death-associated protein kinase 1(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 380nMAssay Description:Binding affinity to DAPK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Citron Rho-interacting kinase(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 2.70E+3nMAssay Description:Binding affinity to CIT (unknown origin)More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Cyclin-dependent kinase 7(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 620nMAssay Description:Binding affinity to CDK7 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Cyclin-dependent kinase 11A(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 2.40E+3nMAssay Description:Binding affinity to CDC2L2 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Cyclin-dependent kinase 11B(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 1.30E+3nMAssay Description:Binding affinity to CDC2L1 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Calcium/calmodulin-dependent protein kinase type 1G(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 4.20E+3nMAssay Description:Binding affinity to CAMK1G (unknown origin)More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Calcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 2.80E+3nMAssay Description:Binding affinity to CAMK1D (unknown origin)More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Calcium/calmodulin-dependent protein kinase type 1(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 4.30E+3nMAssay Description:Binding affinity to CAMK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Atypical kinase COQ8B, mitochondrial(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 4.80E+3nMAssay Description:Binding affinity to ADCK4 (unknown origin)More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase 16(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL

PNG

BDBM50440018(CHEMBL2425628)

Kd: 450nMAssay Description:Binding affinity to STK16 (unknown origin)More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Filter my 34 hits

Targets 34▿
- Mitogen-activated protein kinase 1 1
- Death-associated protein kinase 2 1
- Serine/threonine-protein kinase 17A 1
- Death-associated protein kinase 1 1
- Dual specificity protein kinase TTK 1
- Mitogen-activated protein kinase 4 1
- Death-associated protein kinase 3 1
- Cyclin-dependent kinase 7 1
- Serine/threonine-protein kinase 16 1
- Mitogen-activated protein kinase 6 1
- Cyclin-dependent kinase 11B 1
- Mitogen-activated protein kinase 7 1
- Cyclin-dependent kinase 11A 1
- Serine/threonine-protein kinase DCLK3 1
- Interferon-induced, double-stranded RNA-activated protein kinase 1
- LIM domain kinase 1 1
- Ribosomal protein S6 kinase alpha-1 1
- LIM domain kinase 2 1
- Calcium/calmodulin-dependent protein kinase type 1D 1
- Calcium/calmodulin-dependent protein kinase type 1G 1
- NUAK family SNF1-like kinase 2 1
- Mitogen-activated protein kinase 15 1
- Atypical kinase COQ8A, mitochondrial 1
- Serine/threonine-protein kinase Nek7 1
- Calcium/calmodulin-dependent protein kinase type 1 1
- Serine/threonine-protein kinase Nek5 1
- Myosin light chain kinase family member 4 1
- Serine/threonine-protein kinase Nek1 1
- Atypical kinase COQ8B, mitochondrial 1
- Citron Rho-interacting kinase 1
- MAP kinase-interacting serine/threonine-protein kinase 1 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Dual specificity mitogen-activated protein kinase kinase 4 1
- Platelet-derived growth factor receptor beta 1
Publications 1▿
- Bioorg Med Chem Lett 23: 1486-92 (2013) 34
Institutions 1▿
- Roche Palo Alto 34
Affinity: 1.2E+2 to 1.1E+4 nM▿
- Kd 34
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0