BDBM504403 US11040984, Compound 3

SMILES: COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1N1CC2(CCN(C)CC2)OC1=O

InChI Key: InChIKey=NDPDENJSSNGRDR-UHFFFAOYSA-N

Data: 2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 504403   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor(L858R) (Homo sapiens (Human))	BDBM504403 (US11040984, Compound 3) Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1N1CC2(CCN(C)CC2)OC1=O Show InChI InChI=1S/C23H23ClFN5O3/c1-29-8-6-23(7-9-29)12-30(22(31)33-23)18-10-14-17(11-19(18)32-2)26-13-27-21(14)28-16-5-3-4-15(24)20(16)25/h3-5,10-11,13H,6-9,12H2,1-2H3,(H,26,27,28)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
MEDSHINE DISCOVERY INC. US Patent					Assay Description Buffer formulation: a buffer consisted of 50 mM HEPES (pH 7.5), 0.01% BSA, 5 mM MgCl2, 0.1 mM Orthovanadate. After the buffer was formulated, an enzy...				US Patent US11040984 (2021)
					More data for this Ligand-Target Pair
EGFR (del 746-750) (Homo sapiens (Human))	BDBM504403 (US11040984, Compound 3) Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1N1CC2(CCN(C)CC2)OC1=O Show InChI InChI=1S/C23H23ClFN5O3/c1-29-8-6-23(7-9-29)12-30(22(31)33-23)18-10-14-17(11-19(18)32-2)26-13-27-21(14)28-16-5-3-4-15(24)20(16)25/h3-5,10-11,13H,6-9,12H2,1-2H3,(H,26,27,28)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
MEDSHINE DISCOVERY INC. US Patent					Assay Description Buffer formulation: a buffer consisted of 50 mM HEPES (pH 7.5), 0.01% BSA, 5 mM MgCl2, 0.1 mM Orthovanadate. After the buffer was formulated, an enzy...				US Patent US11040984 (2021)
					More data for this Ligand-Target Pair