BDBM504408 US11040984, Compound 6

SMILES: COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1N1CC2(CCN(C)CC2)OC1=O

InChI Key: InChIKey=PZYWOGPJGHUXFZ-UHFFFAOYSA-N

Data: 2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 504408   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
EGFR (del 746-750) (Homo sapiens (Human))	BDBM504408 (US11040984, Compound 6) Show SMILES COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1N1CC2(CCN(C)CC2)OC1=O Show InChI InChI=1S/C23H22Cl2FN5O3/c1-30-7-5-23(6-8-30)11-31(22(32)34-23)17-9-13-16(10-18(17)33-2)27-12-28-21(13)29-15-4-3-14(24)19(25)20(15)26/h3-4,9-10,12H,5-8,11H2,1-2H3,(H,27,28,29)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
MEDSHINE DISCOVERY INC. US Patent					Assay Description Buffer formulation: a buffer consisted of 50 mM HEPES (pH 7.5), 0.01% BSA, 5 mM MgCl2, 0.1 mM Orthovanadate. After the buffer was formulated, an enzy...				US Patent US11040984 (2021)
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM504408 (US11040984, Compound 6) Show SMILES COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1N1CC2(CCN(C)CC2)OC1=O Show InChI InChI=1S/C23H22Cl2FN5O3/c1-30-7-5-23(6-8-30)11-31(22(32)34-23)17-9-13-16(10-18(17)33-2)27-12-28-21(13)29-15-4-3-14(24)19(25)20(15)26/h3-4,9-10,12H,5-8,11H2,1-2H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.0150	n/a	n/a	n/a	n/a	n/a	n/a
MEDSHINE DISCOVERY INC. US Patent					Assay Description Buffer formulation: a buffer consisted of 50 mM HEPES (pH 7.5), 0.01% BSA, 5 mM MgCl2, 0.1 mM Orthovanadate. After the buffer was formulated, an enzy...				US Patent US11040984 (2021)
					More data for this Ligand-Target Pair