BDBM50441390 CHEMBL2435921

SMILES CC(NCc1cnccc1-c1ccccc1F)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=DUHJCDZMEGDEOZ-UHFFFAOYSA-N

Data  2 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50441390   

TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50441390(CHEMBL2435921)
Show SMILES CC(NCc1cnccc1-c1ccccc1F)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C22H17F7N2/c1-13(14-8-16(21(24,25)26)10-17(9-14)22(27,28)29)31-12-15-11-30-7-6-18(15)19-4-2-3-5-20(19)23/h2-11,13,31H,12H2,1H3
Affinity DataEC50:  204nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50441390(CHEMBL2435921)
Show SMILES CC(NCc1cnccc1-c1ccccc1F)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C22H17F7N2/c1-13(14-8-16(21(24,25)26)10-17(9-14)22(27,28)29)31-12-15-11-30-7-6-18(15)19-4-2-3-5-20(19)23/h2-11,13,31H,12H2,1H3
Affinity DataEC50:  2.04E+3nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayMore data for this Ligand-Target Pair