BDBM50441569 CHEMBL2436981::US10485800, Example 4::US9814704, Example 4

SMILES Nc1ccc(cn1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1

InChI Key InChIKey=YVKIJUOXNIWLHR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50441569   

TargetCytochrome P450 2C9(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441569(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Affinity DataIC50:  1.37E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as inhibition of midazolam metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441569(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as inhibition of diclofenac metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Mus musculus)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441569(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Affinity DataIC50:  430nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
The University Of Rochester

US Patent
LigandPNGBDBM50441569(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Affinity DataIC50: <100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
The University Of Rochester

US Patent
LigandPNGBDBM50441569(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Affinity DataIC50:  19nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
The University Of Rochester

US Patent
LigandPNGBDBM50441569(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Affinity DataIC50: <100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441569(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human wild type LRRK2 by qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed