BDBM356235 BDBM50441572::US10485800, Example 1::US9814704, Example 36

SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1

InChI Key InChIKey=IQUNSUVMFDGCPH-XMHGGMMESA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 356235   

LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human wild type LRRK2 by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50:  550nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCytochrome P450 2D6(Human)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as inhibition of diclofenac metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50: <100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCytochrome P450 2C9(Human)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as inhibition of midazolam metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed