BDBM50442178 CHEMBL2441600::US9187424, 124

SMILES COc1ccc(NC(=O)C2=C(CC(NC2=O)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c2ccc(C)cc2)cc1

InChI Key InChIKey=FBBPRPJENPWDPL-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50442178   

TargetAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50442178(CHEMBL2441600 | US9187424, 124)
Affinity DataIC50:  7nMpH: 7.4Assay Description:The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50442178(CHEMBL2441600 | US9187424, 124)
Affinity DataIC50:  55nMpH: 7.4Assay Description:The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50442178(CHEMBL2441600 | US9187424, 124)
Affinity DataIC50:  15nMpH: 7.4 T: 2°CAssay Description:MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50442178(CHEMBL2441600 | US9187424, 124)
Affinity DataIC50:  17nMAssay Description:Inhibition of mouse recombinant MGAT2 expressed in Sf9 cell membrane using 2-oleoylglycerol and oleoyl-CoA as substrates incubated for 10 mins by LCM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-acylglycerol O-acyltransferase 2(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50442178(CHEMBL2441600 | US9187424, 124)
Affinity DataIC50:  7nMAssay Description:Inhibition of human MGAT2 by LC/MS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-acylglycerol O-acyltransferase 2(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50442178(CHEMBL2441600 | US9187424, 124)
Affinity DataIC50:  15nMAssay Description:Inhibition of human MGAT2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50442178(CHEMBL2441600 | US9187424, 124)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human recombinant MGAT2 expressed in Sf9 cell membrane using 2-monooleglycerol and [H3]-oleoyl-CoA as substrates incubated for 20 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50442178(CHEMBL2441600 | US9187424, 124)
Affinity DataIC50:  4.26E+3nMpH: 7.4 T: 2°CAssay Description:MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...More data for this Ligand-Target Pair
In DepthDetails US Patent