BDBM50442585 GW823296X::ORVEPITANT

SMILES C[C@@H](N(C)C(=O)N1CC[C@@H](C[C@@H]1c1ccc(F)cc1C)N1CCN2[C@@H](CCC2=O)C1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=XWNBGDJPEXZSQM-VZOBGQTKSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50442585   

TargetSubstance-P receptor(Rattus norvegicus (rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442585(GW823296X | ORVEPITANT)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442585(GW823296X | ORVEPITANT)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442585(GW823296X | ORVEPITANT)
Affinity DataKi:  940nMAssay Description:Inhibition of sigma1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442585(GW823296X | ORVEPITANT)
Affinity DataKi:  2.27E+3nMAssay Description:Inhibition of platelet activating factor receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed