BDBM504430 (2S,4R)-1-((S)-2-(tert-butyl)- 17-(4-((1-((1SR,4SR)-4- (hydroxymethyl)cyclohexyl)- 2-(3- (trifluoromethyl)benzamido)- 1H-benzo[d]imidazol-5- yl)methyl)piperazin-1-yl)-4- oxo-6,9,12-tetraoxa-3- azatetradecanoyl)-4- hydroxy-N-(4-(4- methylthiazol-5- yl)benzyl)pyrrolidine-2- carboxamide::US11065231, Example 14

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCN2CCN(Cc3ccc4n(C5CC[C@H](CO)CC5)c(NC(=O)c5cccc(c5)C(F)(F)F)nc4c3)CC2)C(C)(C)C)cc1

InChI Key InChIKey=CEHWWKJHLYDSGM-AFKPILQTSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504430   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM504430((2S,4R)-1-((S)-2-(tert-butyl)- 17-(4-((1-((1SR,4SR...)
Affinity DataIC50: <30nMAssay Description:A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent