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BDBM50443132 CHEMBL3086175::US9221797, 42

SMILES: O=C(Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1)c1ncc([nH]1)C#N

InChI Key: InChIKey=UURBEBBVEFUFRK-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50443132   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM50443132
PNG
(CHEMBL3086175 | US9221797, 42)
Show SMILES O=C(Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C23H27N5O2/c24-15-19-16-25-22(26-19)23(29)27-21-7-6-17(8-9-28-10-12-30-13-11-28)14-20(21)18-4-2-1-3-5-18/h4,6-7,14,16H,1-3,5,8-13H2,(H,25,26)(H,27,29)
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.43n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50443132
PNG
(CHEMBL3086175 | US9221797, 42)
Show SMILES O=C(Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C23H27N5O2/c24-15-19-16-25-22(26-19)23(29)27-21-7-6-17(8-9-28-10-12-30-13-11-28)14-20(21)18-4-2-1-3-5-18/h4,6-7,14,16H,1-3,5,8-13H2,(H,25,26)(H,27,29)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443132
PNG
(CHEMBL3086175 | US9221797, 42)
Show SMILES O=C(Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C23H27N5O2/c24-15-19-16-25-22(26-19)23(29)27-21-7-6-17(8-9-28-10-12-30-13-11-28)14-20(21)18-4-2-1-3-5-18/h4,6-7,14,16H,1-3,5,8-13H2,(H,25,26)(H,27,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS in mouse BMDM cells


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair