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BDBM50445264 CHEMBL3103650

SMILES: CC(=O)c1cn(C)c2ccc(cc12)-c1ccc(C=C2NC(=S)NC2=O)s1

InChI Key: InChIKey=VVYKIXXMXONAEM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50445264   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Perforin-1


(Homo sapiens (Human))
BDBM50445264
PNG
(CHEMBL3103650)
Show SMILES CC(=O)c1cn(C)c2ccc(cc12)-c1ccc(C=C2NC(=S)NC2=O)s1
Show InChI InChI=1S/C19H15N3O2S2/c1-10(23)14-9-22(2)16-5-3-11(7-13(14)16)17-6-4-12(26-17)8-15-18(24)21-19(25)20-15/h3-9H,1-2H3,(H2,20,21,24,25)
NCI pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.30E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


J Med Chem 56: 9542-55 (2014)


Article DOI: 10.1021/jm401604x
BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
More data for this
Ligand-Target Pair