BDBM50445514 CHEMBL3103040::US11345702, Table 1.33::US20230390274, Compound A-32

SMILES COc1ccc(cc1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1

InChI Key InChIKey=FUCWZIFGSAFUAO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50445514   

Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50445514(CHEMBL3103040 | US11345702, Table 1.33 | US2023039...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50445514(CHEMBL3103040 | US11345702, Table 1.33 | US2023039...)
Affinity DataIC50:  1.36E+3nMAssay Description:Inhibition of ALDH1A1 (unknown origin) using NAD+/propionaldehyde as substrate after 15 mins by UV-fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Epirium Bio

US Patent
LigandPNGBDBM50445514(CHEMBL3103040 | US11345702, Table 1.33 | US2023039...)
Affinity DataIC50: <100nMAssay Description:The in vitro biochemical assay can be performed in white, 384 plates in total 20 μl reaction volume consisting of 10 nM of 15-PGDH/HPGD (R&D Sys...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Epirium Bio

US Patent
LigandPNGBDBM50445514(CHEMBL3103040 | US11345702, Table 1.33 | US2023039...)
Affinity DataIC50:  6.40nMAssay Description:The in vitro biochemical assay can be performed in white, 384 plates in total 20 μl reaction volume consisting of 10 nM of 15-PGDH/HPGD (R&D Sys...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50445514(CHEMBL3103040 | US11345702, Table 1.33 | US2023039...)
Affinity DataIC50:  6.40nMAssay Description:A hydroxyprostaglandin dehydrogenase inhibition screening biochemical assay can be performed to assess the synthesized inhibitors provided herein. Pr...More data for this Ligand-Target Pair
In DepthDetails US Patent