BDBM50446179 CHEMBL3109011::US9518026, Example 39::US9956214, Compound 1517

SMILES CCOc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C

InChI Key InChIKey=XZLFLNWUBLMFQW-UHFFFAOYSA-N

Data  10 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50446179   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Syntide 2 as substrate assessed as decrease in depletion of ATP after 90 mins by Kinase glo l...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK as substrate after 90 mins by Kinase glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase(Plasmodium falciparum)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataIC50:  2.22E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum PKG assessed as decrease in depletion of ATP by Kinase glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUncharacterized protein(Cryptosporidium parvum)
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair