BDBM50446514 CHEMBL3110076

SMILES CCOc1ccc(N2CCN([C@@H](C)C2)c2noc(n2)C2(CCC2)NC(C)=O)c(C)c1

InChI Key InChIKey=ZRAMOXHZLIIJGI-INIZCTEOSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50446514   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50446514(CHEMBL3110076)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50446514(CHEMBL3110076)
Affinity DataIC50:  54nMAssay Description:Inhibition of human ACC2 assessed as acetylCoA to malonylCoA conversion after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50446514(CHEMBL3110076)
Affinity DataIC50:  193nMAssay Description:Inhibition of human ACC1 assessed as acetylCoA to malonylCoA conversion after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50446514(CHEMBL3110076)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of human ACC2 expressed in CHOK1 cells assessed as acetylCoA to malonylCoA conversion after 1 hr by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50446514(CHEMBL3110076)
Affinity DataIC50:  427nMAssay Description:Inhibition of mouse ACC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50446514(CHEMBL3110076)
Affinity DataIC50:  89nMAssay Description:Inhibition of mouse ACC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50446514(CHEMBL3110076)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed