BDBM50448775 CHEMBL3128055

SMILES CCNc1nc2ccc(cc2n1-c1ncnc(N)n1)C#CC(C)(C)O

InChI Key InChIKey=NDZPPXQOOUNQTQ-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50448775   

TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448775(CHEMBL3128055)
Affinity DataKi:  60nMAssay Description:Binding affinity to N-terminal GST-tagged recombinant human PAK4 kinase domain expressed in Escherichia coli using KKRNRRLSVA as substrate preincubat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448775(CHEMBL3128055)
Affinity DataKi: >4.50E+3nMAssay Description:Binding affinity to N-terminal GST-His-tagged recombinant human PAK1 kinase domain expressed in Escherichia coli BL21 using KKRNRRLSVA as sustrate pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448775(CHEMBL3128055)
Affinity DataIC50:  66nMAssay Description:Inhibition of human recombinant PAK4 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448775(CHEMBL3128055)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of human recombinant PAK1 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed