BDBM50450369 SIALYL LEWIS X::Sialyl LeX::Sialyl lewis-x::sLex::sialyl LewisX

SMILES [H][C@]1(O[C@@](C[C@H](O)[C@H]1NC(C)=O)(O[C@H]1[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]([C@H](O)CO)[C@H](O[C@@H]2O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)[C@@H](NC(C)=O)C=O)[C@@H]1O)C(O)=O)[C@H](O)[C@H](O)CO

InChI Key InChIKey=LAQPKDLYOBZWBT-NYLDSJSYSA-N

Data  39 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 50450369   

TargetL-selectin(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+6nMAssay Description:In vitro inhibitory activity of compound was determined against Selectin L binding by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  5.50E+6nMAssay Description:Concentration required to inhibit the interaction of Selectin P and HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+6nMAssay Description:In vitro inhibitory activity of compound was determined against Selectin P binding by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataKd:  1.00E+6nMAssay Description:Affinity of compound to Selectin E was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  1.09E+6nMAssay Description:Compound was tested in a cell-free SLe-polyacrylamide glycoconjugate binding assay (assay B) in Selectin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >3.00E+6nMAssay Description:Tested in a cell-free SLe-polyacrylamide glycoconjugate binding assay (assay A) in P-selectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  1.09E+6nMAssay Description:Compound was tested in a cell-free SLe-polyacrylamide glycoconjugate binding assay (assay B) in Selectin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  1.30E+6nMAssay Description:Compound was tested in a cell-free SLe-polyacrylamide glycoconjugate binding assay (assay B) in P-selectin; value ranges from 1.3-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was evaluated for the Selectin E binding activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  5.00E+5nMAssay Description:Ability to inhibit sialyl Lewis X binding to Selectin E was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.00E+5nMAssay Description:Compound was tested for its ability to inhibit the binding to recombinant human Selectin E immobilized on SPA beads of radiolabeled HL60 cell membran...More data for this Ligand-Target Pair
In DepthDetails Article
TargetE-selectin(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.00E+6nMAssay Description:Compound was tested for its ability to inhibit sialyl Lewis X dependent binding of HL-60 cells to Selectin E fusion proteinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.00E+5nMAssay Description:In vitro inhibitory activity against binding of Selectin E to human recombinant AGP (alpha-1 acid glycoprotein) containing sLex derivativeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  5.00E+6nMAssay Description:Concentration required to inhibit the interaction of Selectin E and HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  5.00E+6nMAssay Description:Concentration required to inhibit the interaction of Selectin P and HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  7.00E+5nMAssay Description:Inhibitory concentration against E-selectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.00E+6nMAssay Description:In vitro inhibition of HL60 (human leukemia) cell binding to human recombinant e-selectin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-selectin(Mus musculus)
Texas Biotechnology

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  2.00E+6nMAssay Description:In vitro inhibitory activity against sialyl Lewis X expressing HL60 cell binding Selectin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  2.00E+6nMAssay Description:In vitro inhibitory activity against sialyl Lewis X expressing HL60 cell binding Selectin PMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-selectin(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory concentration against blocking of Selectin L during migration of inflammatory cells to inflammatory siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  6.00E+5nMAssay Description:Inhibitory concentration against blocking of E-selectin during migration of inflammatory cells to inflammatory siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory concentration against blocking of Selectin P during migration of inflammatory cells to inflammatory siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity against human chimeric Selectin P-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-selectin(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity against human chimeric L-selectin-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  6.00E+5nMAssay Description:Inhibitory activity against human chimeric E-selectin-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Mus musculus)
Kanebo

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+6nMAssay Description:Blocking activity using seletin-IgG chimeras in a Selectin P competitive binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-selectin(Mus musculus)
Texas Biotechnology

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+6nMAssay Description:Blocking activity using seletin-IgG chimeras in a Selectin L competitive binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  6.00E+5nMAssay Description:In vitro inhibitory activity against Selectin E-sialyl Lewis X (sLex) bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-selectin(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Selectin L bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  6.00E+5nMAssay Description:Displacement of sialyl Lewis X (sLex) from selectin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Selectin P bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-selectin(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.50E+6nMAssay Description:Tested in vitro for the concentration to inhibit sLex bearing HL-60 cells binding to Selectin L-IgG fusion proteinsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.30E+6nMAssay Description:Tested in vitro for the concentration to inhibit sLex bearing HL-60 cells binding to Selectin E-IgG fusion proteins by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.40E+6nMAssay Description:Tested in vitro for the concentration to inhibit sLex bearing HL-60 cells binding to Selectin P-IgG fusion proteinsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: <1.00E+6nMAssay Description:Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin B recep...More data for this Ligand-Target Pair
In DepthDetails
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.00E+5nMAssay Description:Ability to inhibit the binding to Selectin E immobilized on SPA beads of radiolabeled HL-60 cell membrane was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  5.00E+6nMAssay Description:Concentration required to inhibit the interaction of Selectin E and HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  5.00E+6nMAssay Description:Concentration required to inhibit the interaction of Selectin E and HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  5.50E+6nMAssay Description:Concentration required to inhibit the interaction of Selectin P and HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  6.00E+5nMAssay Description:In vitro inhibitory activity of compound was determined against Selectin E binding by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed