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BDBM50450507 CHEMBL4175922

SMILES: O[C@@H]1CN(C[C@H]1COc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(Cl)cc1Cl

InChI Key: InChIKey=BXJNNQDYLWMHBF-YVEFUNNKSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50450507   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))
BDBM50450507
PNG
(CHEMBL4175922)
Show SMILES O[C@@H]1CN(C[C@H]1COc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H15Cl2FN2O4S/c19-13-2-4-18(15(20)5-13)28(25,26)23-8-12(17(24)9-23)10-27-14-3-1-11(7-22)16(21)6-14/h1-6,12,17,24H,8-10H2/t12-,17+/m0/s1
PDB

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UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 expressed in BHK/AC9 or HEK MSR2 cells assessed as inhibition of PF-04674114-induced Ca2+ flux pre-incubated for 1...


J Med Chem 61: 9738-9755 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01317
BindingDB Entry DOI: 10.7270/Q2CJ8H2P
More data for this
Ligand-Target Pair