BDBM504512 US11065249, Example 25::rac-2-{5-[(3-ethoxypyridin-2- yl)oxy]pyridin-3-yl}-N-[(3R,5S)-5- fluoropiperidin-3-yl]pyrimidine-5- carboxamide, trifluoroacetate salt
SMILES: CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CNC[C@@H](F)C1
InChI Key: InChIKey=RTJSFNSXPOCCRB-DLBZAZTESA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human)) | BDBM504512![]() (US11065249, Example 25 | rac-2-{5-[(3-ethoxypyridi...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ... | US Patent US11065249 (2021) | |||||||||||
More data for this Ligand-Target Pair |